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Bland Altman Interpretation

Journal list Help Journal ListBiochem Med (Zagreb)v.25(2); 2015 JunPMC4470095 Biochem bland altman plot . excel Med (Zagreb). 2015 Jun; 25(2): 141–151. Published online 2015 Jun 5. doi:  10.11613/BM.2015.015PMCID: PMC4470095Understanding Bland

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Altman analysisDavide GiavarinaClinical Chemistry and Hematology Laboratory, San Bortolo Hospital, Vicenza, ItalyCorresponding author: Email: ti.aznecivsslu@aniravaig.edivadAuthor information â–º Article notes â–º Copyright and License information â–ºReceived bland altman plot r 2015 Feb 23; Accepted 2015 Apr 30.Copyright notice This article has been cited by other articles in PMC.AbstractIn a contemporary clinical laboratory it is very common to have to assess the agreement between two quantitative methods of measurement. The correct statistical approach to assess this degree of agreement is reporting bland altman results not obvious. Correlation and regression studies are frequently proposed. However, correlation studies the relationship between one variable and another, not the differences, and it is not recommended as a method for assessing the comparability between methods.In 1983 Altman and Bland (B&A) proposed an alternative analysis, based on the quantification of the agreement between two quantitative measurements by studying the mean difference and constructing limits of agreement.The B&A plot analysis is a simple way to evaluate a bias between the mean differences, and to estimate an agreement interval, within which 95% of the differences of the second method, compared to the first one, fall. Data can be analyzed both as unit differences plot and as percentage differences plot.The B&A plot method only defines the intervals of agreements, it does not say whether those limits are acceptable or not. Acceptable limits must be defined a priori, based on cl

Technology, Auckland 1020, New Zealand. Email. Reviewer: Alan M Batterham, Sport and Exercise Science, University of Bath, Bath BA2 7AY, UK. An instrument that has been calibrated against a criterion measure with a sample of subjects

Understanding Bland Altman Analysis

is sometimes checked against the criterion in a validity study with another bland altman plot example sample.  In a spreadsheet-based simulation of such calibration and validity studies, a Bland-Altman plot of difference vs mean values

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for the instrument and criterion shows a systematic proportional bias in the instrument's readings, even though none is present.  This artifactual bias arises in a Bland-Altman plot of any measures with substantial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470095/ random error. In contrast, a regression analysis of the criterion vs the instrument shows no bias.  The regression analysis also provides complete statistics for recalibrating the instrument, if bias develops or if random error changes since the last calibration.  The Bland-Altman analysis of validity should therefore be abandoned in favor of regression. KEYWORDS: calibration, method comparison, random error, systematic error, standard error of the http://www.sportsci.org/jour/04/wghbias.htm estimate. Reprintpdf· Reprintdoc·Spreadsheet·Reviewer's Commentary For comparison of one method with another, Bland and Altman (1986) advised researchers to use the two methods on a group of subjects, then plot the difference scores against the mean for each subject.  Such plots have become a standard accessory in validity or method-comparison studies, and their original paper has been cited over 9000 times.  In this article I use a spreadsheet to show that the plots can lead to an incorrect conclusion about the validity of a measure, and I urge researchers to use regression when comparing measures. Bland and Altman devised their plot to steer researchers away from what they considered was misuse of the correlation coefficient as a measure of validity. The misuse amounted to regarding the correlation coefficient as the most important or even the only measure of the relationship between two measures.  The problem with the correlation coefficient is that the two measures might be highly correlated, yet there could be substantial differences in the two measures across their range of values.  An appropriate comparison of the two measures needs to highlight such differences—hence the Bland-Altman plot,

& Reprints Resources Clinical Chemistry Trainee Council Clinical Case Studies Clinical Chemistry Guide to Scientific Writing Clinical http://clinchem.aaccjnls.org/content/48/5/799 Chemistry Guide to Manuscript Review Journal Club Podcasts Q&A Translated Content Abstracts Submit Contact Other PublicationsThe Journal of Applied Laboratory Medicine User menu Subscribe My alerts Log in Search Search for this keyword Advanced search Other PublicationsThe Journal of Applied Laboratory Medicine Subscribe My alerts Log in Search for this bland altman keyword Advanced Search Home AboutClinical Chemistry Editorial Board Most Read Most Cited Alerts ArticlesCurrent Issue Early Release Future Table of Contents Archive Browse by Subject Info forAuthors Reviewers Subscribers Advertisers Permissions & Reprints Resources Clinical Chemistry Trainee Council Clinical Case Studies Clinical Chemistry Guide to Scientific Writing Clinical Chemistry Guide bland altman plot to Manuscript Review Journal Club Podcasts Q&A Translated Content Abstracts Submit Contact LetterLetters Application of the Bland–Altman Plot for Interpretation of Method-Comparison Studies: A Critical Investigation of Its Practice Katy Dewitte, Colette Fierens, Dietmar Stöckl, Linda M. Thienpont Published May 2002 Katy DewitteFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteColette FierensFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteDietmar StöcklFind this author on Google ScholarFind this author on PubMedSearch for this author on this siteLinda M. ThienpontFind this author on Google ScholarFind this author on PubMedSearch for this author on this site ArticleFigures & DataInfo & Metrics PDF To the Editor: Current guidelines for the combined graphical/statistical interpretation of method-comparison studies (1) include a scatter plot combined with correlation and regression analysis (2) and/or a difference plot combined with calculation of the 2s lim

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