Error Related Functional Connectivity Of The Habenula In Humans

Please note that Internet Explorer version 8.x will not be supported as of January 1, 2016. Please refer to this blog post for more information. Close ScienceDirectSign inSign in using your ScienceDirect credentialsUsernamePasswordRemember meForgotten username or password?Sign in via your institutionOpenAthens loginOther institution loginHelpJournalsBooksRegisterJournalsBooksRegisterSign inHelpcloseSign in using your ScienceDirect credentialsUsernamePasswordRemember meForgotten username or password?Sign in via your institutionOpenAthens loginOther institution login Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. Help Direct export Export file RIS(for EndNote, Reference Manager, ProCite) BibTeX Text RefWorks Direct Export Content Citation Only Citation and Abstract Advanced search JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. This page uses JavaScript to progressively load the article content as a user scrolls. Click the View full text link to bypass dynamically loaded article content. View full text NeuroImage: ClinicalVolume 4, 2014, Pages 585–592 Open Access Error-related functional connectivity of the thalamus in cocaine dependenceSheng Zhanga, , , Sien Hua, Sarah R. Bednarskia, Emily Erdmana, Chiang-shan R. Lia, b, ca Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USAb Inter-departmental Neuroscience Program, Yale University, New Haven, CT 06520, USAc Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USAReceived 21 November 2013, Revised 13 January 2014, Accepted 26 January 2014, Available online 7 February 2014Highlights•Error-related thalamic-vmPFC connectivity is altered in cocaine misuse.•This altered connectivity is associated with impaired self control.•This deficit is associated with recent cocaine use in women but not men.AbstractError processing is a critical component of cognitive control, an executive function that has been widely implicated in substance misuse. In previous studies we showed that error related activations of the thalamus predicted relapse to drug use in c

Title: Frontiers in Human Neuroscience ISSN: 1662-5161 (Online) Publisher:Frontiers Media S.A. Country of publisher:Switzerland Language of fulltext:English Full-text formats available: PDF, HTML, ePUB, XML AUTHORS Jaime Shinsuke Ide (Yale University) Chiang-shan R Li (Yale University) Chiang-shan R Li (Yale University) Chiang-shan R Li (Yale University) EDITORIAL INFORMATION Blind peer review Editorial Board Instructions for authors Time From Submission to Publication: 14 weeks Abstract | Full Text Error detection is critical to the shaping of goal-oriented behavior. Recent studies in non-human http://www.sciencedirect.com/science/article/pii/S2213158214000163 primates delineated a circuit involving the lateral habenula (LH) and ventral tegmental area (VTA) in error detection. Neurons in the LH increased activity, preceding decreased activity in the VTA, to a missing reward, indicating a feedforward signal from the LH to VTA. In the current study we used connectivity analyses to reveal this pathway in humans. In 59 https://doaj.org/article/e5b35a43ab1d42529d493af533511d9d adults performing a stop signal task during functional magnetic resonance imaging (fMRI), we identified brain regions showing greater psychophysiological interaction with the habenula during stop error as compared to stop success trials. These regions included a cluster in the VTA/substantia nigra (SN), internal segment of globus pallidus (GPi), bilateral amygdala, and insula. Furthermore, using Granger causality and mediation analyses, we showed that the habenula Granger caused the VTA/SN, establishing the direction of this interaction, and that the habenula mediated the functional connectivity between the amgydala and VTA/SN during error processing. To our knowledge, these findings are the first to demonstrate a feedforward influence of the habenula on the VTA/SN during error detection in humans. 9,158 Journals 6,406 searchable at Article level 128 Countries 2,323,825 Articles FAQs Interacting with DOAJ Open Access Information Best Practice Download metadata New Journals Feed Our members Our publisher members Our sponsors Our volunteers © 2016 DOAJ. The DOAJ site and its metadata are licensed under CC BY-SA Contact us / IS4OA / Cottage Labs LLP

LinkedIn Reddit Download Full-text PDF Resting-state functional connectivity of the human habenula in healthy individuals: Associations with subclinical depressionArticle https://www.researchgate.net/publication/298899520_Resting-state_functional_connectivity_of_the_human_habenula_in_healthy_individuals_Associations_with_subclinical_depression (PDF Available) in Human Brain Mapping · March 2016 with 77 ReadsDOI: 10.1002/hbm.23179 1st Benjamin A. Ely2nd Junqian Xu33.6 · Icahn School of Medicine at Mount Sinai+ 23rd Wayne K Goodman45.24 · Icahn https://www.cambridge.org/core/journals/the-international-journal-of-neuropsychopharmacology/article/the-effects-of-methylphenidate-on-resting-state-striatal-thalamic-and-global-functional-connectivity-in-healthy-adults/6CA3C220D170A9DA1A7AF01AD903F4DD School of Medicine at Mount SinaiLast Emily R Stern29.34 · UnknownShow more authorsAbstractIntroduction: The habenula (Hb) is postulated to play a critical role in reward and aversion error related processing across species, including humans, and has been increasingly implicated in depression. However, technical constraints have limited in vivo investigation of the human Hb, and its function remains poorly characterized. We sought to overcome these challenges by examining the whole-brain resting-state functional connectivity of the Hb and its possible relationship to depressive symptomatology using error related functional the high-resolution WU-Minn Human Connectome Project (HCP) dataset. Methods: Anatomical and resting-state functional MRI data from 50 healthy subjects with low or high subclinical depression scores (n = 25 each) were analyzed. Using novel semi-automated segmentation and optimization techniques, we generated individual-specific Hb seeds and calculated whole-brain functional connectivity for the entire cohort and the contrast of high vs. low depression groups. Results: In the entire cohort, the Hb exhibited significant connectivity with key brainstem structures (i.e., ventral tegmental area, substantia nigra, pons) as well as the anterior and posterior cingulate cortices, precuneus, thalamus, and sensorimotor cortex. Multiple regions showed differential Hb connectivity based on subclinical depression scores, including the amygdala, insula, and prefrontal, mid-cingulate, and entorhinal cortices. Conclusions: Hb connectivity findings converged on areas associated with salience processing, sensorimotor systems, and the default mode network. We also detected substantial Hb-brainstem connectivity, consistent with prior histological and animal research. High and low subclinical depression groups exhibited differences in Hb connectivity w

web browser we do not support. To improve your experience please try one of the following options: Chrome (latest version) Firefox (latest version) Internet Explorer 10+ Cancel Log in × Home Only search content I have access to Log in Register Browse subjects What we publish Services About Cambridge Core Institution login Register Log in < Back to search results HomeJournalsThe International Journal of NeuropsychopharmacologyVolume 17 Issue 8The effects of methylphenidate on resting-state st... The The International Journal ofNeuropsychopharmacology Article Article Supplementary materials Aa Aa Volume 17 , Issue 8 Get access Check if you have access via personal or institutional login Log in Register Recommend to librarian The International Journal of Neuropsychopharmacology, Volume 17, Issue 8 August 2014, pp. 1177-1191 The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults Olivia M. Farr (a1), Sheng Zhang (a2), Sien Hu (a2), David Matuskey (a2), Osama Abdelghany (a3), Robert T. Malison (a2) and Chiang-shan R. Li (a1) (a2) (a4) (a1) 1Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, USA(a2) 2Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA(a3) 3Investigational Drug Service, Yale New Haven Hospital, New Haven, CT, USA(a4) 4Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA DOI: http://dx.doi.org/10.1017/S1461145714000674 Published online: 13 May 2014 Abstract AbstractBy blocking dopamine and norepinephrine transporters, methylphenidate affects cognitive performance and regional brain activation in healthy individuals as well as those with neuropsychiatric disorders. Resting-state connectivity evaluates the functional integrity of a network of brain regions. Here, we examined how methylphenidate effects resting-stat