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Health Search databasePMCAll DatabasesAssemblyBioProjectBioSampleBioSystemsBooksClinVarCloneConserved DomainsdbGaPdbVarESTGeneGenomeGEO DataSetsGEO ProfilesGSSGTRHomoloGeneMedGenMeSHNCBI Web SiteNLM CatalogNucleotideOMIMPMCPopSetProbeProteinProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMedPubMed HealthSNPSparcleSRAStructureTaxonomyToolKitToolKitAllToolKitBookToolKitBookghUniGeneSearch termSearch Advanced Journal list Help Journal ListAm J Hum Genetv.93(2); 2013 Aug 8PMC3738834 Am J Hum Genet. 2013 Aug 8; 93(2): 236–248. doi: 10.1016/j.ajhg.2013.06.011PMCID: PMC3738834Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant StatisticsYi-Juan Hu,1 Sonja I. Berndt,2 Stefan Gustafsson,3 Andrea Ganna,3,4 Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Joel Hirschhorn,5,6,7 Kari E. North,8 Erik Ingelsson,3,9 and Dan-Yu Lin10,∗1Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA2Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA3Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University Hospital, 751 85 Uppsala, Sweden4Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden5Divisions of Genetics and Endocrinology and Center for Basic and Translational Obesity Research, Children’s Hospital, Boston, MA 02115, USA6Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA7Department of Genetics, Harvard Medical School, Boston, MA 02115, USA8Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599-8050, USA9Wellcome Trust Centre for Human Genetics, University of