Familywise Error
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may be challenged and removed. (June 2016) (Learn how and when to remove this template message) In statistics, family-wise error rate (FWER) is the probability of making one or more family wise error rate definition false discoveries, or type I errors, among all the hypotheses when performing family wise error t tests multiple hypotheses tests. Contents 1 History 2 Background 2.1 Classification of multiple hypothesis tests 3 Definition 4 Controlling procedures
Family Wise Error Bonferroni
4.1 The Bonferroni procedure 4.2 The Šidák procedure 4.3 Tukey's procedure 4.4 Holm's step-down procedure (1979) 4.5 Hochberg's step-up procedure 4.6 Dunnett's correction 4.7 Scheffé's method 4.8 Resampling procedures 5
Family Wise Error Multiple Regression
Alternative approaches 6 References History[edit] Tukey coined the terms experimentwise error rate and "error rate per-experiment" to indicate error rates that the researcher could use as a control level in a multiple hypothesis experiment.[citation needed] Background[edit] Within the statistical framework, there are several definitions for the term "family": Hochberg & Tamhane defined "family" in 1987 as "any collection of inferences for family wise error anova which it is meaningful to take into account some combined measure of error".[1][pageneeded] According to Cox in 1982, a set of inferences should be regarded a family:[citation needed] To take into account the selection effect due to data dredging To ensure simultaneous correctness of a set of inferences as to guarantee a correct overall decision To summarize, a family could best be defined by the potential selective inference that is being faced: A family is the smallest set of items of inference in an analysis, interchangeable about their meaning for the goal of research, from which selection of results for action, presentation or highlighting could be made (Yoav Benjamini).[citation needed] Classification of multiple hypothesis tests[edit] Main article: Classification of multiple hypothesis tests The following table defines various errors committed when testing multiple null hypotheses. Suppose we have a number m of multiple null hypotheses, denoted by: H1,H2,...,Hm. Using a statistical test, we reject the null hypothesis if the test is declared significant. We do not reject the null hypothesis if the test is non-significant. Summing the test results over Hi will giv
Descriptive Statistics Hypothesis Testing General Properties of Distributions Distributions Normal Distribution Sampling Distributions Binomial and Related Distributions Student's t Distribution Chi-square and F
Family Wise Error Rate Post Hoc
Distributions Other Key Distributions Testing for Normality and Symmetry ANOVA One-way family wise error in statistics ANOVA Factorial ANOVA ANOVA with Random or Nested Factors Design of Experiments ANOVA with Repeated Measures family wise error rate r Analysis of Covariance (ANCOVA) Miscellaneous Correlation Reliability Non-parametric Tests Time Series Analysis Survival Analysis Handling Missing Data Regression Linear Regression Multiple Regression Logistic Regression Multinomial and Ordinal https://en.wikipedia.org/wiki/Family-wise_error_rate Logistic Regression Log-linear Regression Multivariate Descriptive Multivariate Statistics Multivariate Normal Distribution Hotelling’s T-square MANOVA Repeated Measures Tests Box’s Test Factor Analysis Cluster Analysis Appendix Mathematical Notation Excel Capabilities Matrices and Iterative Procedures Linear Algebra and Advanced Matrix Topics Other Mathematical Topics Statistics Tables Bibliography Author Citation Blogs Tools Real Statistics Functions Multivariate Functions Time Series http://www.real-statistics.com/one-way-analysis-of-variance-anova/experiment-wise-error-rate/ Analysis Functions Missing Data Functions Data Analysis Tools Contact Us Experiment-wise error rate We could have conducted the analysis for Example 1 of Basic Concepts for ANOVA by conducting multiple two sample tests. E.g. to decide whether or not to reject the following null hypothesis H0: μ1 = μ2 = μ3 We can use the following three separate null hypotheses: H0: μ1 = μ2 H0: μ2 = μ3 H0: μ1 = μ3 If any of these null hypotheses is rejected then the original null hypothesis is rejected. Note however that if you set α = .05 for each of the three sub-analyses then the overall alpha value is .14 since 1 – (1 – α)3 = 1 – (1 – .05)3 = 0.142525 (see Example 6 of Basic Probability Concepts). This means that the probability of rejecting the null hypothesis even when it is true (type I error) is 14.2525%. For k groups, you would need to run m = COMBIN(k, 2) such tests and so the resulting overall alpha would be 1 – (1 – α)m, a val
or FWER. It is easy to show that if you declare tests significant for \(p < \alpha\) then FWER ≤ \(min(m_0\alpha,1)\). The most commonly used method which controls FWER at level \(\alpha\) is called Bonferroni's method. It rejects https://onlinecourses.science.psu.edu/stat555/node/58 the null hypothesis when \(p < \alpha / m\). (It would be better to http://onlinestatbook.com/glossary/familywise.html use \(m_0\) but we don't know what it is - more on that later.) The Bonferroni method is guaranteed to control FWER, but it has a big problem. It greatly reduces your power to detect real differences. For example, suppose the effect size is 2 and you are doing a t-test, rejecting for p < 0.05. With 10 wise error observations per group, the power is 99%. Now suppose you have 1000 tests, and use the Bonferroni method. That means that to reject, we need p < 0.00005. The power is now only 29%. If you have 10 thousand tests (which is small for genomics studies) the power is only 10%. Sometimes the "Bonferroni-adjusted p-values are reported". They are just: \(p_b=min(mp,1)\). Another simple more powerful but less popular method uses the sorted p-values: family wise error \[p_{(1)}\leq p_{(2)} \leq \cdots \leq p_{(m)}\] Holmes showed that the FWER is controlled with the following algorithm: Compare \(p_{(i)}\) with \(\alpha / (m-i+1)\). Starting from i = 1, reject until \(p_{(i)}\) is greater. The most significant test must therefore pass the Bonferroni criterion. However, if it is significant, the next most significant is tested at a less stringent level. Heuristically, after rejecting the most significant test, we conclude the \(m_0 \leq m-1\) and use \(m-1\) for the next correction, and so on sequentially. The Holmes method is more powerful than the Bonferroni method, but it is still not very powerful. We can also compute "Holmes-adjusted p-values" \(p_{h(i)} = min((m-i+1)p_{(i)},1)\). ‹ 4.1 - Mistakes in Statistical Testing up 4.3 -1995 - Two Huge Steps for Biological Inference › Printer-friendly version Navigation Start Here! Welcome to STAT 555! Faculty login (PSU Access Account) Lessons Lesson 1: Introduction to Cell Biology Lesson 2: Basic Statistical Inference for Bioinformatics Studies Lesson 3: Designing Bioinformatics Experiments Lesson 4: Multiple Testing4.1 - Mistakes in Statistical Testing 4.2 - Controlling Family-wise Error Rate 4.3 -1995 - Two Huge Steps for Biological Inference 4.4 - Estimating \(m_0\) (or \(\pi_0\)) 4.5 - q-Values 4.6 - Using the Histogram of p-values Lesson 5: Microarray Preprocessing Lesson 6: Statistics for Differential Expression in Microarray Studies Lesson 7: L