Home > wise error > familywise error

Familywise Error

Contents

may be challenged and removed. (June 2016) (Learn how and when to remove this template message) In statistics, family-wise error rate (FWER) is the probability of making one or more family wise error rate definition false discoveries, or type I errors, among all the hypotheses when performing family wise error t tests multiple hypotheses tests. Contents 1 History 2 Background 2.1 Classification of multiple hypothesis tests 3 Definition 4 Controlling procedures

Family Wise Error Bonferroni

4.1 The Bonferroni procedure 4.2 The Šidák procedure 4.3 Tukey's procedure 4.4 Holm's step-down procedure (1979) 4.5 Hochberg's step-up procedure 4.6 Dunnett's correction 4.7 Scheffé's method 4.8 Resampling procedures 5

Family Wise Error Multiple Regression

Alternative approaches 6 References History[edit] Tukey coined the terms experimentwise error rate and "error rate per-experiment" to indicate error rates that the researcher could use as a control level in a multiple hypothesis experiment.[citation needed] Background[edit] Within the statistical framework, there are several definitions for the term "family": Hochberg & Tamhane defined "family" in 1987 as "any collection of inferences for family wise error anova which it is meaningful to take into account some combined measure of error".[1][pageneeded] According to Cox in 1982, a set of inferences should be regarded a family:[citation needed] To take into account the selection effect due to data dredging To ensure simultaneous correctness of a set of inferences as to guarantee a correct overall decision To summarize, a family could best be defined by the potential selective inference that is being faced: A family is the smallest set of items of inference in an analysis, interchangeable about their meaning for the goal of research, from which selection of results for action, presentation or highlighting could be made (Yoav Benjamini).[citation needed] Classification of multiple hypothesis tests[edit] Main article: Classification of multiple hypothesis tests The following table defines various errors committed when testing multiple null hypotheses. Suppose we have a number m of multiple null hypotheses, denoted by: H1,H2,...,Hm. Using a statistical test, we reject the null hypothesis if the test is declared significant. We do not reject the null hypothesis if the test is non-significant. Summing the test results over Hi will giv

Descriptive Statistics Hypothesis Testing General Properties of Distributions Distributions Normal Distribution Sampling Distributions Binomial and Related Distributions Student's t Distribution Chi-square and F

Family Wise Error Rate Post Hoc

Distributions Other Key Distributions Testing for Normality and Symmetry ANOVA One-way family wise error in statistics ANOVA Factorial ANOVA ANOVA with Random or Nested Factors Design of Experiments ANOVA with Repeated Measures family wise error rate r Analysis of Covariance (ANCOVA) Miscellaneous Correlation Reliability Non-parametric Tests Time Series Analysis Survival Analysis Handling Missing Data Regression Linear Regression Multiple Regression Logistic Regression Multinomial and Ordinal https://en.wikipedia.org/wiki/Family-wise_error_rate Logistic Regression Log-linear Regression Multivariate Descriptive Multivariate Statistics Multivariate Normal Distribution Hotelling’s T-square MANOVA Repeated Measures Tests Box’s Test Factor Analysis Cluster Analysis Appendix Mathematical Notation Excel Capabilities Matrices and Iterative Procedures Linear Algebra and Advanced Matrix Topics Other Mathematical Topics Statistics Tables Bibliography Author Citation Blogs Tools Real Statistics Functions Multivariate Functions Time Series http://www.real-statistics.com/one-way-analysis-of-variance-anova/experiment-wise-error-rate/ Analysis Functions Missing Data Functions Data Analysis Tools Contact Us Experiment-wise error rate We could have conducted the analysis for Example 1 of Basic Concepts for ANOVA by conducting multiple two sample tests. E.g. to decide whether or not to reject the following null hypothesis H0: μ1 = μ2 = μ3 We can use the following three separate null hypotheses: H0: μ1 = μ2 H0: μ2 = μ3 H0: μ1 = μ3 If any of these null hypotheses is rejected then the original null hypothesis is rejected. Note however that if you set α = .05 for each of the three sub-analyses then the overall alpha value is .14 since 1 – (1 – α)3 = 1 – (1 – .05)3 = 0.142525 (see Example 6 of Basic Probability Concepts). This means that the probability of rejecting the null hypothesis even when it is true (type I error) is 14.2525%. For k groups, you would need to run m = COMBIN(k, 2) such tests and so the resulting overall alpha would be 1 – (1 – α)m, a val

or FWER. It is easy to show that if you declare tests significant for \(p < \alpha\) then FWER ≤ \(min(m_0\alpha,1)\). The most commonly used method which controls FWER at level \(\alpha\) is called Bonferroni's method. It rejects https://onlinecourses.science.psu.edu/stat555/node/58 the null hypothesis when \(p < \alpha / m\). (It would be better to http://onlinestatbook.com/glossary/familywise.html use \(m_0\) but we don't know what it is - more on that later.) The Bonferroni method is guaranteed to control FWER, but it has a big problem. It greatly reduces your power to detect real differences. For example, suppose the effect size is 2 and you are doing a t-test, rejecting for p < 0.05. With 10 wise error observations per group, the power is 99%. Now suppose you have 1000 tests, and use the Bonferroni method. That means that to reject, we need p < 0.00005. The power is now only 29%. If you have 10 thousand tests (which is small for genomics studies) the power is only 10%. Sometimes the "Bonferroni-adjusted p-values are reported". They are just: \(p_b=min(mp,1)\). Another simple more powerful but less popular method uses the sorted p-values: family wise error \[p_{(1)}\leq p_{(2)} \leq \cdots \leq p_{(m)}\] Holmes showed that the FWER is controlled with the following algorithm: Compare \(p_{(i)}\) with \(\alpha / (m-i+1)\). Starting from i = 1, reject until \(p_{(i)}\) is greater. The most significant test must therefore pass the Bonferroni criterion. However, if it is significant, the next most significant is tested at a less stringent level. Heuristically, after rejecting the most significant test, we conclude the \(m_0 \leq m-1\) and use \(m-1\) for the next correction, and so on sequentially. The Holmes method is more powerful than the Bonferroni method, but it is still not very powerful. We can also compute "Holmes-adjusted p-values" \(p_{h(i)} = min((m-i+1)p_{(i)},1)\). ‹ 4.1 - Mistakes in Statistical Testing up 4.3 -1995 - Two Huge Steps for Biological Inference › Printer-friendly version Navigation Start Here! Welcome to STAT 555! Faculty login (PSU Access Account) Lessons Lesson 1: Introduction to Cell Biology Lesson 2: Basic Statistical Inference for Bioinformatics Studies Lesson 3: Designing Bioinformatics Experiments Lesson 4: Multiple Testing4.1 - Mistakes in Statistical Testing 4.2 - Controlling Family-wise Error Rate 4.3 -1995 - Two Huge Steps for Biological Inference 4.4 - Estimating \(m_0\) (or \(\pi_0\)) 4.5 - q-Values 4.6 - Using the Histogram of p-values Lesson 5: Microarray Preprocessing Lesson 6: Statistics for Differential Expression in Microarray Studies Lesson 7: L

 

Related content

anova family error

Anova Family Error table id toc tbody tr td div id toctitle Contents div ul li a href Experiment Wise Error Rate a li li a href Familywise Error Rate Anova a li li a href Per Comparison Error Rate a li li a href Decision Wise Error Rate a li ul td tr tbody table p may be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the probability of relatedl making one or more false discoveries or type I errors family wise error rate formula among all

comparison wise error

Comparison Wise Error table id toc tbody tr td div id toctitle Contents div ul li a href Comparisonwise Error a li li a href Experiment Wise Error Anova a li li a href Experiment Wise Error Definition a li ul td tr tbody table p the simple question posed by an analysis of variance - do at least two treatment means differ It may be that embedded in a group of treatments there is only relatedl one control treatment to which every other treatment should be compared experiment wise error and comparisons among the non-control treatments may be uninteresting

correction for familywise error

Correction For Familywise Error table id toc tbody tr td div id toctitle Contents div ul li a href Family Wise Error Multiple Regression a li li a href Family Wise Error Anova a li ul td tr tbody table p may be challenged and removed June Learn how and when relatedl to remove this template message In statistics family-wise family wise error rate error rate FWER is the probability of making one fwe correction or more false discoveries or type I errors among all the hypotheses when performing multiple family wise error bonferroni hypotheses tests Contents History Background Classification

comparison-wise error rate definition

Comparison-wise Error Rate Definition table id toc tbody tr td div id toctitle Contents div ul li a href Experiment Wise Error Rate a li li a href Comparisonwise Error Rate a li li a href Familywise Error Rate Calculator a li ul td tr tbody table p the simple question posed by an analysis of variance - do at least two treatment means differ It may relatedl be that embedded in a group of treatments there is family wise error rate definition only one control treatment to which every other treatment should be compared and p h id Experiment

comparison-wise and experiment-wise error

Comparison-wise And Experiment-wise Error table id toc tbody tr td div id toctitle Contents div ul li a href Experiment Wise Error Rate a li li a href Experiment Wise Type Error a li li a href Decision Wise Error Rate a li ul td tr tbody table p Descriptive Statistics Hypothesis Testing General Properties of Distributions Distributions Normal relatedl Distribution Sampling Distributions Binomial and Related Distributions Student's experiment wise error anova t Distribution Chi-square and F Distributions Other Key Distributions experiment wise error definition Testing for Normality and Symmetry ANOVA One-way ANOVA Factorial ANOVA ANOVA with Random or Nested

comparison wise error rate

Comparison Wise Error Rate table id toc tbody tr td div id toctitle Contents div ul li a href Comparison Wise Error Rate Definition a li li a href Family Wise Error Rate R a li li a href How To Calculate Family Wise Error Rate a li ul td tr tbody table p the simple question posed by an analysis of variance - do at least two treatment means differ relatedl It may be that embedded in a group of experiment wise error rate treatments there is only one control treatment to which every other treatment experimentwise error rate

comparison-wise type 1 error

Comparison-wise Type Error table id toc tbody tr td div id toctitle Contents div ul li a href Experiment Wise Error a li li a href Decision Wise Error Rate a li li a href Familywise Error Rate Calculator a li ul td tr tbody table p Descriptive Statistics Hypothesis Testing General Properties of Distributions Distributions Normal Distribution Sampling Distributions Binomial and Related Distributions Student's t relatedl Distribution Chi-square and F Distributions Other Key Distributions comparison wise error rate Testing for Normality and Symmetry ANOVA One-way ANOVA Factorial ANOVA ANOVA with family wise type error Random or Nested Factors Design

comparison-wise type i error

Comparison-wise Type I Error table id toc tbody tr td div id toctitle Contents div ul li a href Comparison Wise Error Rate a li li a href Experiment Wise Error Anova a li li a href Per Comparison Error Rate a li li a href Experimentwise Alpha a li ul td tr tbody table p Bioassays Resources DNA RNABLAST relatedl Basic Local Alignment Search Tool BLAST p h id Comparison Wise Error Rate p Stand-alone E-UtilitiesGenBankGenBank BankItGenBank SequinGenBank tbl asnGenome WorkbenchInfluenza VirusNucleotide DatabasePopSetPrimer-BLASTProSplignReference experiment wise type error Sequence RefSeq RefSeqGeneSequence Read Archive SRA SplignTrace ArchiveUniGeneAll DNA RNA Resources Data

decision wise error rate

Decision Wise Error Rate table id toc tbody tr td div id toctitle Contents div ul li a href Familywise Error Rate Calculator a li li a href Per Comparison Error Rate a li li a href Familywise Error Rate Anova a li ul td tr tbody table p the experimentwise error rate is where alpha ew p h id Per Comparison Error Rate p is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons experiment wise error anova were each to be done at the level

error wise

Error Wise table id toc tbody tr td div id toctitle Contents div ul li a href Experimentwise Error Definition a li li a href How To Calculate Family Wise Error Rate a li li a href Family Wise Error Calculator a li li a href Familywise Error Rate Anova a li ul td tr tbody table p the experimentwise error rate is where alpha ew decision wise error rate is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons per comparison error rate were each to

experiment wise error correction

Experiment Wise Error Correction table id toc tbody tr td div id toctitle Contents div ul li a href How To Calculate Family Wise Error Rate a li li a href Decision Wise Error Rate a li li a href Family Wise Error Calculator a li ul td tr tbody table p Descriptive Statistics Hypothesis Testing General Properties of Distributions Distributions Normal Distribution Sampling Distributions Binomial and Related relatedl Distributions Student's t Distribution Chi-square and F Distributions Other experiment wise error rate definition Key Distributions Testing for Normality and Symmetry ANOVA One-way ANOVA Factorial comparison wise error rate ANOVA ANOVA

experimentwise and comparison wise error rate

Experimentwise And Comparison Wise Error Rate table id toc tbody tr td div id toctitle Contents div ul li a href Experiment Wise Error Anova a li li a href Experimentwise Alpha a li li a href Per Comparison Error Rate a li li a href Experimentwise Alpha Definition a li ul td tr tbody table p the experimentwise error rate is where alpha ew p h id Experimentwise Alpha p is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons p h id Per Comparison Error

experiment wise error

Experiment Wise Error table id toc tbody tr td div id toctitle Contents div ul li a href Experiment Wise Error Definition a li li a href Comparison Wise Error a li li a href Family Wise Error a li li a href Comparison Wise Error Rate a li ul td tr tbody table p the experimentwise error rate is where alpha ew p h id Comparison Wise Error p is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons type error were each to be done

experimentwise error rate wikipedia

Experimentwise Error Rate Wikipedia table id toc tbody tr td div id toctitle Contents div ul li a href Experiment Wise Error a li li a href Per Comparison Error Rate a li li a href Family Wise Error Rate Post Hoc a li ul td tr tbody table p may be challenged and removed June Learn how and when relatedl to remove this template message In statistics family-wise familywise error rate calculator error rate FWER is the probability of making one p h id Experiment Wise Error p or more false discoveries or type I errors among all the

experimentwise error

Experimentwise Error table id toc tbody tr td div id toctitle Contents div ul li a href Type Error a li li a href Comparisonwise Error Rate a li ul td tr tbody table p the experimentwise error rate is where alpha ew experimentwise alpha is experimentwise error rate alpha pc is the per-comparison error rate and c is the number of comparisons For example if independent comparisons p h id Type Error p were each to be done at the level then the probability that at least one of them would result in a Type I error is -

experimental wise error correction

Experimental Wise Error Correction table id toc tbody tr td div id toctitle Contents div ul li a href Family Wise Error Rate Correction a li li a href Experiment Wise Error Definition a li li a href Experiment Wise Error Rate a li li a href Comparison Wise Error Rate a li ul td tr tbody table p Descriptive Statistics Hypothesis Testing General Properties of Distributions Distributions Normal Distribution Sampling Distributions Binomial and Related Distributions Student's t Distribution Chi-square and F Distributions Other relatedl Key Distributions Testing for Normality and Symmetry ANOVA One-way ANOVA family wise error correction Factorial

family wise error rate bonferroni

Family Wise Error Rate Bonferroni table id toc tbody tr td div id toctitle Contents div ul li a href Family Wise Error Rate R a li li a href Family Wise Error Rate Formula a li li a href Family Wise Error Rate Correction a li li a href Family Wise Error Calculator a li ul td tr tbody table p may be challenged and removed June Learn how and when to relatedl remove this template message In statistics family-wise error family wise error rate post hoc rate FWER is the probability of making one or more p h

family wise error anova

Family Wise Error Anova table id toc tbody tr td div id toctitle Contents div ul li a href Per Comparison Error Rate a li li a href Familywise Non Coverage Error Rate a li ul td tr tbody table p describe a number of different ways of testing which means are different Before describing relatedl the tests it is necessary to consider two different ways how to calculate family wise error rate of thinking about error and how they are relevant to doing multiple comparisons family wise error calculator Error Rate per Comparison PC This is simply the Type

family wise error rate fmri

Family Wise Error Rate Fmri table id toc tbody tr td div id toctitle Contents div ul li a href How To Calculate Family Wise Error Rate a li li a href Family Wise Error Rate Formula a li li a href Family Wise Error Rate Correction a li ul td tr tbody table p may be challenged and removed June Learn how and when to remove this template message In statistics family-wise error relatedl rate FWER is the probability of making one or family wise error rate post hoc more false discoveries or type I errors among all the

family wise error rate r

Family Wise Error Rate R table id toc tbody tr td div id toctitle Contents div ul li a href Familywise Error Rate Anova a li li a href Familywise Error Rate Calculator a li li a href How To Calculate Family Wise Error Rate a li ul td tr tbody table p may be challenged and removed June Learn how and when to relatedl remove this template message In statistics family-wise family wise error rate post hoc error rate FWER is the probability of making one or familywise error rate more false discoveries or type I errors among all

family wise error rate anova

Family Wise Error Rate Anova table id toc tbody tr td div id toctitle Contents div ul li a href Family Wise Error Rate R a li li a href How To Calculate Family Wise Error Rate a li li a href Family Wise Error Rate Definition a li ul td tr tbody table p may be challenged and removed June Learn how and when to remove this relatedl template message In statistics family-wise error rate FWER familywise error rate anova is the probability of making one or more false discoveries or family wise error rate post hoc type I

family rate error

Family Rate Error table id toc tbody tr td div id toctitle Contents div ul li a href Familywise Error Rate a li li a href Family Wise Error Calculator a li li a href Comparison Wise Error Rate a li ul td tr tbody table p may be challenged and removed June Learn how and when to remove this template message In statistics family-wise error rate FWER is the relatedl probability of making one or more false discoveries or family wise error rates type I errors among all the hypotheses when performing multiple hypotheses tests Contents decision wise error

family wise error correction fmri

Family Wise Error Correction Fmri table id toc tbody tr td div id toctitle Contents div ul li a href Family Wise Error Rate Correction a li li a href Family Wise Error Calculator a li li a href Familywise Error Rate Anova a li li a href Cluster Threshold Fmri a li ul td tr tbody table p Health Search databasePMCAll DatabasesAssemblyBioProjectBioSampleBioSystemsBooksClinVarCloneConserved DomainsdbGaPdbVarESTGeneGenomeGEO DataSetsGEO ProfilesGSSGTRHomoloGeneMedGenMeSHNCBI relatedl Web SiteNLM CatalogNucleotideOMIMPMCPopSetProbeProteinProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMedPubMed p h id Family Wise Error Rate Correction p HealthSNPSparcleSRAStructureTaxonomyToolKitToolKitAllToolKitBookToolKitBookghUniGeneSearch termSearch Advanced Journal list Help Journal ListHHS Author familywise error correction ManuscriptsPMC Neuroimage Author manuscript available

family wise error fmri

Family Wise Error Fmri table id toc tbody tr td div id toctitle Contents div ul li a href Family Wise Error Correction a li li a href Familywise Error Rate Anova a li li a href Experiment Wise Error Rate a li li a href Family Wise Error Rate Post Hoc a li ul td tr tbody table p an excellent introduction to the issue of FWE in neuroimaging in very readable fashion You're encouraged to check it out Many relatedl scientific fields have had to confront the problem p h id Family Wise Error Correction p of assessing