Controlling Family Wise Error Rate
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may be challenged and removed. (June 2016) (Learn how and when to remove this template message) In statistics, family-wise error rate (FWER) is the probability of making one or more false discoveries, or type I
Error Rate Familywise
errors, among all the hypotheses when performing multiple hypotheses tests. Contents 1 History family wise error rate post hoc 2 Background 2.1 Classification of multiple hypothesis tests 3 Definition 4 Controlling procedures 4.1 The Bonferroni procedure 4.2 The Šidák family wise error rate r procedure 4.3 Tukey's procedure 4.4 Holm's step-down procedure (1979) 4.5 Hochberg's step-up procedure 4.6 Dunnett's correction 4.7 Scheffé's method 4.8 Resampling procedures 5 Alternative approaches 6 References History[edit] Tukey coined the terms experimentwise
How To Calculate Family Wise Error Rate
error rate and "error rate per-experiment" to indicate error rates that the researcher could use as a control level in a multiple hypothesis experiment.[citation needed] Background[edit] Within the statistical framework, there are several definitions for the term "family": Hochberg & Tamhane defined "family" in 1987 as "any collection of inferences for which it is meaningful to take into account some combined measure of error".[1][pageneeded] According to Cox
Family Wise Error Rate Formula
in 1982, a set of inferences should be regarded a family:[citation needed] To take into account the selection effect due to data dredging To ensure simultaneous correctness of a set of inferences as to guarantee a correct overall decision To summarize, a family could best be defined by the potential selective inference that is being faced: A family is the smallest set of items of inference in an analysis, interchangeable about their meaning for the goal of research, from which selection of results for action, presentation or highlighting could be made (Yoav Benjamini).[citation needed] Classification of multiple hypothesis tests[edit] Main article: Classification of multiple hypothesis tests The following table defines various errors committed when testing multiple null hypotheses. Suppose we have a number m of multiple null hypotheses, denoted by: H1,H2,...,Hm. Using a statistical test, we reject the null hypothesis if the test is declared significant. We do not reject the null hypothesis if the test is non-significant. Summing the test results over Hi will give us the following table and related random variables: Null hypothesis is true (H0) Alternative hypothesis is true (HA) Total Test is declared significant V {\displaystyle V} S {\displaystyle S} R {\displaysty
or FWER. It is easy to show that if you declare tests significant for \(p < \alpha\) then FWER ≤ \(min(m_0\alpha,1)\). The most family wise error rate definition commonly used method which controls FWER at level \(\alpha\) is called Bonferroni's
Family Wise Error Rate Correction
method. It rejects the null hypothesis when \(p < \alpha / m\). (It would be better to per comparison error rate use \(m_0\) but we don't know what it is - more on that later.) The Bonferroni method is guaranteed to control FWER, but it has a big problem. It https://en.wikipedia.org/wiki/Family-wise_error_rate greatly reduces your power to detect real differences. For example, suppose the effect size is 2 and you are doing a t-test, rejecting for p < 0.05. With 10 observations per group, the power is 99%. Now suppose you have 1000 tests, and use the Bonferroni method. That means that to reject, we need p < 0.00005. The power https://onlinecourses.science.psu.edu/stat555/node/58 is now only 29%. If you have 10 thousand tests (which is small for genomics studies) the power is only 10%. Sometimes the "Bonferroni-adjusted p-values are reported". They are just: \(p_b=min(mp,1)\). Another simple more powerful but less popular method uses the sorted p-values: \[p_{(1)}\leq p_{(2)} \leq \cdots \leq p_{(m)}\] Holmes showed that the FWER is controlled with the following algorithm: Compare \(p_{(i)}\) with \(\alpha / (m-i+1)\). Starting from i = 1, reject until \(p_{(i)}\) is greater. The most significant test must therefore pass the Bonferroni criterion. However, if it is significant, the next most significant is tested at a less stringent level. Heuristically, after rejecting the most significant test, we conclude the \(m_0 \leq m-1\) and use \(m-1\) for the next correction, and so on sequentially. The Holmes method is more powerful than the Bonferroni method, but it is still not very powerful. We can also compute "Holmes-adjusted p-values" \(p_{h(i)} = min((m-i+1)p_{(i)},1)\). ‹ 4.1 - Mistakes in Statistical Testing up 4.3 -1995 - Two Huge Steps for Biological Inference › Printer-friendly version Navigat
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