Family-wise Error Rate
Contents |
may be challenged and removed. (June 2016) (Learn how and when to remove this template message) In statistics, family-wise error rate (FWER) is the probability of making family-wise error rate bonferroni correction one or more false discoveries, or type I errors, among all family-wise error rate vs fdr the hypotheses when performing multiple hypotheses tests. Contents 1 History 2 Background 2.1 Classification of multiple hypothesis fwe familywise error tests 3 Definition 4 Controlling procedures 4.1 The Bonferroni procedure 4.2 The Šidák procedure 4.3 Tukey's procedure 4.4 Holm's step-down procedure (1979) 4.5 Hochberg's step-up procedure 4.6 Dunnett's correction false discovery rate 4.7 Scheffé's method 4.8 Resampling procedures 5 Alternative approaches 6 References History[edit] Tukey coined the terms experimentwise error rate and "error rate per-experiment" to indicate error rates that the researcher could use as a control level in a multiple hypothesis experiment.[citation needed] Background[edit] Within the statistical framework, there are several definitions for the term "family": Hochberg & Tamhane
Family Wise Error Rate Formula
defined "family" in 1987 as "any collection of inferences for which it is meaningful to take into account some combined measure of error".[1][pageneeded] According to Cox in 1982, a set of inferences should be regarded a family:[citation needed] To take into account the selection effect due to data dredging To ensure simultaneous correctness of a set of inferences as to guarantee a correct overall decision To summarize, a family could best be defined by the potential selective inference that is being faced: A family is the smallest set of items of inference in an analysis, interchangeable about their meaning for the goal of research, from which selection of results for action, presentation or highlighting could be made (Yoav Benjamini).[citation needed] Classification of multiple hypothesis tests[edit] Main article: Classification of multiple hypothesis tests The following table defines various errors committed when testing multiple null hypotheses. Suppose we have a number m of multiple null hypotheses, denoted by: H1,H2,...,Hm. Using a statistical test, we reject the null hypothesis if the test is decla
or FWER. It is easy to show that if you declare tests significant for \(p < \alpha\) then FWER ≤ \(min(m_0\alpha,1)\). The most commonly used method which controls FWER at level \(\alpha\) is called Bonferroni's
Family Wise Error Rate Example
method. It rejects the null hypothesis when \(p < \alpha / m\). (It would per comparison error rate be better to use \(m_0\) but we don't know what it is - more on that later.) The Bonferroni method is experiment wise error rate guaranteed to control FWER, but it has a big problem. It greatly reduces your power to detect real differences. For example, suppose the effect size is 2 and you are doing a t-test, rejecting https://en.wikipedia.org/wiki/Family-wise_error_rate for p < 0.05. With 10 observations per group, the power is 99%. Now suppose you have 1000 tests, and use the Bonferroni method. That means that to reject, we need p < 0.00005. The power is now only 29%. If you have 10 thousand tests (which is small for genomics studies) the power is only 10%. Sometimes the "Bonferroni-adjusted p-values are reported". They are just: \(p_b=min(mp,1)\). Another simple more https://onlinecourses.science.psu.edu/stat555/node/58 powerful but less popular method uses the sorted p-values: \[p_{(1)}\leq p_{(2)} \leq \cdots \leq p_{(m)}\] Holmes showed that the FWER is controlled with the following algorithm: Compare \(p_{(i)}\) with \(\alpha / (m-i+1)\). Starting from i = 1, reject until \(p_{(i)}\) is greater. The most significant test must therefore pass the Bonferroni criterion. However, if it is significant, the next most significant is tested at a less stringent level. Heuristically, after rejecting the most significant test, we conclude the \(m_0 \leq m-1\) and use \(m-1\) for the next correction, and so on sequentially. The Holmes method is more powerful than the Bonferroni method, but it is still not very powerful. We can also compute "Holmes-adjusted p-values" \(p_{h(i)} = min((m-i+1)p_{(i)},1)\). ‹ 4.1 - Mistakes in Statistical Testing up 4.3 -1995 - Two Huge Steps for Biological Inference › Printer-friendly version Navigation Start Here! Welcome to STAT 555! Faculty login (PSU Access Account) Lessons Lesson 1: Introduction to Cell Biology Lesson 2: Basic Statistical Inference for Bioinformatics Studies Lesson 3: Designing Bioinformatics Experiments Lesson 4: Multiple Testing4.1 - Mistakes in Statistical Testing 4.2 - Controlling Family-wise Error Rate 4.3 -1995 - Two Huge Steps for Biological Inference 4.4 - Estimating \(m_0\) (or \(\pi_0\)) 4.5 - q-Values 4.6 - Using the Histo
or more absolutely true null hypotheses in a family of several absolutely true null hypotheses. Rejecting an absolutely true null hypothesis is known as http://core.ecu.edu/psyc/wuenschk/docs30/FamilywiseAlpha.htm a "Type One Error." It is important to keep in mind that one cannot make a Type I error unless one tests an absolutely true null hypothesis. Accordingly, if absolutely true null hypotheses are unlikely to be encountered, then the unconditional probability of making a Type I error will be quite small. Psychologists and some others act as if error rate they think they will burn in hell for an eternity if they ever make even a single Type I error -- that is, if they ever reject a null hypothesis when, in fact, that hypothesis is absolutely true. I and many others are of the opinion that the unconditional probability of making a Type I error is close to zero, since wise error rate it is highly unlikely that one will ever test a null hypothesis that is absolutely true. Why worry so much about making an error that is almost impossible to make? There exists a variety of techniques for capping familywise alpha at some value, usually .05. Why .05? Maybe .05 is, sometimes, a reasonable criterion for statistical significance when making a single comparison, but is it really reasonable to cap familywise alpha at .05? Even if it is, what reasonably constitutes the family for which one should cap familywise alpha at .05? Is it the family of hypotheses that I am testing for this particular outcome variable in this particular research project? I am testing for all comparisons make in this particular research project? I am testing this month, this year, or during my lifetime? All psychologists are testing this month, this year, or whenever? Many times I have asked this question about what reasonably constitutes a family of comparisons for which alpha should be capped at .05. I have never been satisfied with any answer I ha
be down. Please try the request again. Your cache administrator is webmaster. Generated Sat, 15 Oct 2016 14:54:43 GMT by s_ac15 (squid/3.5.20)