Familywise Error Rate Fwer
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may be challenged and removed. (June 2016) (Learn how and when to remove this template message) In statistics, family-wise familywise error rate anova error rate (FWER) is the probability of making one or
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more false discoveries, or type I errors, among all the hypotheses when performing multiple hypotheses tests. fwer vs fdr Contents 1 History 2 Background 2.1 Classification of multiple hypothesis tests 3 Definition 4 Controlling procedures 4.1 The Bonferroni procedure 4.2 The Šidák procedure 4.3 family wise error calculator Tukey's procedure 4.4 Holm's step-down procedure (1979) 4.5 Hochberg's step-up procedure 4.6 Dunnett's correction 4.7 Scheffé's method 4.8 Resampling procedures 5 Alternative approaches 6 References History[edit] Tukey coined the terms experimentwise error rate and "error rate per-experiment" to indicate error rates that the researcher could use as a control level
Experiment Wise Error Rate
in a multiple hypothesis experiment.[citation needed] Background[edit] Within the statistical framework, there are several definitions for the term "family": Hochberg & Tamhane defined "family" in 1987 as "any collection of inferences for which it is meaningful to take into account some combined measure of error".[1][pageneeded] According to Cox in 1982, a set of inferences should be regarded a family:[citation needed] To take into account the selection effect due to data dredging To ensure simultaneous correctness of a set of inferences as to guarantee a correct overall decision To summarize, a family could best be defined by the potential selective inference that is being faced: A family is the smallest set of items of inference in an analysis, interchangeable about their meaning for the goal of research, from which selection of results for action, presentation or highlighting could be made (Yoav Benjamini).[citation needed] Classification of multiple hypothesis tests[edit] Main article: Classifica
or FWER. It is easy to show that if you declare tests significant for \(p < \alpha\) then FWER ≤ \(min(m_0\alpha,1)\). The most commonly used method which controls FWER at level \(\alpha\) is called per comparison error rate Bonferroni's method. It rejects the null hypothesis when \(p < \alpha / m\). (It family wise error rate post hoc would be better to use \(m_0\) but we don't know what it is - more on that later.) The Bonferroni method
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is guaranteed to control FWER, but it has a big problem. It greatly reduces your power to detect real differences. For example, suppose the effect size is 2 and you are doing a t-test, https://en.wikipedia.org/wiki/Family-wise_error_rate rejecting for p < 0.05. With 10 observations per group, the power is 99%. Now suppose you have 1000 tests, and use the Bonferroni method. That means that to reject, we need p < 0.00005. The power is now only 29%. If you have 10 thousand tests (which is small for genomics studies) the power is only 10%. Sometimes the "Bonferroni-adjusted p-values are reported". They are just: \(p_b=min(mp,1)\). Another https://onlinecourses.science.psu.edu/stat555/node/58 simple more powerful but less popular method uses the sorted p-values: \[p_{(1)}\leq p_{(2)} \leq \cdots \leq p_{(m)}\] Holmes showed that the FWER is controlled with the following algorithm: Compare \(p_{(i)}\) with \(\alpha / (m-i+1)\). Starting from i = 1, reject until \(p_{(i)}\) is greater. The most significant test must therefore pass the Bonferroni criterion. However, if it is significant, the next most significant is tested at a less stringent level. Heuristically, after rejecting the most significant test, we conclude the \(m_0 \leq m-1\) and use \(m-1\) for the next correction, and so on sequentially. The Holmes method is more powerful than the Bonferroni method, but it is still not very powerful. We can also compute "Holmes-adjusted p-values" \(p_{h(i)} = min((m-i+1)p_{(i)},1)\). ‹ 4.1 - Mistakes in Statistical Testing up 4.3 -1995 - Two Huge Steps for Biological Inference › Printer-friendly version Navigation Start Here! Welcome to STAT 555! Faculty login (PSU Access Account) Lessons Lesson 1: Introduction to Cell Biology Lesson 2: Basic Statistical Inference for Bioinformatics Studies Lesson 3: Designing Bioinformatics Experiments Lesson 4: Multiple Testing4.1 - Mistakes in Statistical Testing 4.2 - Controlling Family-wise Error Rate 4.3 -1995 - Two Huge Steps for Biological Inference 4.4 - Estimating \(m_0\) (or \(\pi_0\)) 4.5 - q-Values 4
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