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Help Journal ListSleepv.35(11); PMC3466800 Sleep. 2012 Nov 1; 35(11): 1529–1539. Published online cass return codes 2012 Nov 1. doi: 10.5665/sleep.2204PMCID: PMC3466800A Randomized, Double-Blind, Placebo-Controlled Study of an Oral, Extended-Release Formulation of Phentermine/Topiramate for the Treatment of cass error and warning codes Obstructive Sleep Apnea in Obese AdultsDavid H. Winslow, MD,1 Charles H. Bowden, MD,2 Karen P. DiDonato, RN, MSN,2 and Pamela A. McCullough, PhD11Kentucky Research Group, Louisville, KY2VIVUS, Inc., Mountain View, CAAddress correspondence to: David H. Winslow, MD, Kentucky Research Group, 1169 Eastern Parkway,
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Suite 2243, Louisville, KY 40217Phone: (502) 479.1217Fax: (502) 479.1218, ; Email: moc.dempeelsyk@wolsniwdAuthor information ► Article notes ► Copyright and License information ►Received 2011 Oct; Revised 2011 Jun; Accepted 2012 Jul.Copyright © 2012 Associated Professional Sleep Societies, LLC.This article has been cited by other articles in PMC.AbstractStudy Objectives:To evaluate safety and efficacy of phentermine 15 mg plus extended-release topiramate 92 mg for treatment of moderate to severe obstructive sleep apnea (OSA) in obese adults.Design:This phase 2, randomized, double-blind, placebo-controlled study included 2-week screening and 28-week treatment periods. Overnight polysomnography was performed at baseline, Week 8, and Week 28.Setting:Single-center study conducted from August 2008 to September 2009.Participants:Forty-five subjects with moderate to severe OSA not receiving positive airway pressure (PAP) treatment with body mass index of 30-40 kg/m2.Interventions:S
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